Page 76 - Livre électronique des RFTP 2025

P30. CLINICAL AND PROGNOSTIC CHARACTERISTICS OF

OBSTRUCTIVE SLEEP APNEA AMONG SMOKERS

SARA.TRIMECH, EMNA. BEN JEMIA, HEND. OUERTANI, SIWAR.REJEB, HAIFA. ZAIBI,
JIHEN. BEN AMAR

PNEUMOLOGY DEPARTMENT OF CHARLES NICOLLE HOSPITAL. TUNIS EL MANAR UNIVERSITY,
TUNIS MEDICAL FACULTY, TUNISIA

Introduction : Smoking is a major public challenge, with great impact on individual
and societal health. Referring to literature, few studies have examined the
relationship between smoking and Obstructive sleep apnea (OSA).

Objective : To study the role of smoking in the genesis of OSA and the worsening
of its symptoms and determine prognostic characteristics of this sleep disorder
among smokers.

Methods : A cross-sectional study carried out in the Pneumology Department at
the Charles Nicolle University Hospital in Tunis from January 2023 to June 2024,
enrolling 172 patients with a confirmed OSA by a respiratory polygraphy realized in
hospital. We divided patients into two groups according to smoking status. G1:
smoking patients and G2: non-smoking patients. Statistical analyses were
performed to compare the results of the two groups.

Results : A total of 172 patients were included with a sex ratio at 3, a mean age at
59±13 years and 47 patients (27.3%) were smokers. Univariate study showed that
smoking patients were predominantly men (p<0.001). There was no significant

association between smoking status and cardiovascular and metabolic
comorbidities except for COPD (p=0.001) and insomnia (p=0.04). Screening scores
such NoSAS and StopBang were more performant in G1 (p=0.03 and p= 0.01
respectively). Polygraphy finding showed that smoking patients had more severe
OSA with higher apnea-hypopnea index (p=0.007), apnea index (p=0.01), oxygen
desaturation index (p=0.006), and higher capnia (p=0.04). As a result G1 had more
frequent recourse to CPAP use (p=0.036). Multivariate study concluded that male
sex and hypercapnia characterize the presentation of OSA in patients who smoke
with respectively (OR=1.85; p<0.05) and (OR=5.57; p=0.015).

Conclusion : This study shows that OSA appears to be more severe in smoking
patients, underlining the need for targeted interventions for smokers at risk of OSA
and the importance of encouraging smoking cessation.

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